Opium,
narcotic drug produced from the drying resin of unripe capsules of the opium poppy, Papaver
somniferum. Opium is grown mainly in Turkey and India. The
legitimate world demand for opium amounts to about 680 metric
tons a year, but many times that amount is distributed
illegally.
In its commercial form, opium is a chestnut-colored
globular mass, sticky and rather soft, but hardening
from within as it ages. It is processed into the alkaloid
morphine
which has long served as the chief painkiller in
medical practice, although synthetic substitutes such as
meperidine (trade name Demerol) are now available. Heroin, a
derivative of morphine, is about three times more
potent. Codeine is another important opium alkaloid.
The molecules of opiates have painkilling properties
similar to those of compounds called endorphins or enkephalins produced in the body. Being of similar
structure, the opiate molecules occupy many of the
same nerve-receptor sites and bring on the same analgesic
effect as the body's natural painkillers. Opiates first
produce a
feeling of pleasure and euphoria, but with their
continued use the body demands larger amounts to reach the
same sense of well-being. Withdrawal is extremely
uncomfortable, and addicts typically continue taking
the drug to avoid pain rather than to attain the initial
state of euphoria. Malnutrition, respiratory complications,
and low
blood pressure are some of the illnesses associated
withaddiction.
As long ago as 100 AD, opium had been used as a folk
medicine, taken with a beverage or swallowed as a
solid. Only toward the middle of the 17th century, when
opiumsmoking was introduced into China, did any serious
addiction problems arise. In the 18th century opium addiction was so serious there that the Chinese made
many
attempts to prohibit opium cultivation and opium
trade with Western countries. At the same time opium made its
way to Europe and North America, where addiction grew out
of its prevalent use as a painkiller.
With the invention of the hypodermic syringe during
the American Civil War, the injection of morphine became
indispensable in treating patients who had to
undergo some of the newly developed surgical operations.
Physicians of that time hoped that injecting morphine directly
into the blood stream would avoid the addictive effects of
smoking or eating opium, but instead it proved more
addictive. With the discovery of heroin in 1898 came a similar hope,
but this more potent drug created a much stronger
dependency than opium or morphine. Today opium is sold on the street as a powder or
dark brown solid and is smoked, eaten, or injected.
Heroin addicts in the U.S. number close to half a million
people. Although the synthetic narcotic methadone has been
used to offer addicts some relief from opiates, it is itself
addictive. Complete recovery from opiate addiction requires
years of social and psychological rehabilitation.
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